Trimethylamine N-oxide promotes demyelination in spontaneous hypertension rats through enhancing pyroptosis of oligodendrocytes

BACKGROUND: Hypertension is a leading risk factor for cerebral small vessel disease (CSVD), a brain microvessels dysfunction accompanied by white matter lesions (WML). Trimethylamine N-oxide (TMAO), a metabolite of intestinal flora, is correlated with cardiovascular and aging diseases. Here, we expl...

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Detalles Bibliográficos
Autores principales: Ji, Xiaotan, Tian, Long, Niu, Shenna, Yao, Shumei, Qu, Chuanqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441869/
https://www.ncbi.nlm.nih.gov/pubmed/36072486
http://dx.doi.org/10.3389/fnagi.2022.963876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441869/
https://www.ncbi.nlm.nih.gov/pubmed/36072486
http://dx.doi.org/10.3389/fnagi.2022.963876

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