High-circulating gut microbiota-dependent metabolite trimethylamine N-oxide is associated with poor prognosis in pulmonary arterial hypertension

AIMS: We aimed to examine the hypothesis that circulating trimethylamine-N-oxide (TMAO) levels serve as a biomarker in pulmonary arterial hypertension (PAH), and to determine whether 3,3-dimethyl-1-butanol (DMB), a TMAO inhibitor, exerted a protective effect in monocrotaline (MCT)-induced PAH rats....

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Detalles Bibliográficos
Autores principales: Yang, Yicheng, Zeng, Qixian, Gao, Jianing, Yang, Beilan, Zhou, Jingjing, Li, Ke, Li, Li, Wang, Anxin, Li, Xin, Liu, Zhihong, Luo, Qin, Zhao, Zhihui, Liu, Bingyang, Xue, Jing, Jiang, Xue, Konerman, Matthew C, Zheng, Lemin, Xiong, Changming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442843/
https://www.ncbi.nlm.nih.gov/pubmed/36071697
http://dx.doi.org/10.1093/ehjopen/oeac021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442843/
https://www.ncbi.nlm.nih.gov/pubmed/36071697
http://dx.doi.org/10.1093/ehjopen/oeac021

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