Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1

BACKGROUND: The cyclin-dependent kinase 7 (CDK7) inhibitor THZ1 represses multiple cancer cells. However, its tumor-repressive efficiency in wild-type p53 breast cancer cells remains controversial. METHODS: We conducted various assays, including CCK8, colony formation, flow cytometry, western blotti...

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Detalles Bibliográficos
Autores principales: Wang, Yueyuan, Zhang, Zhihao, Mi, Xuguang, Li, Mingxi, Huang, Dan, Song, Tingting, Qi, Xiaoyan, Yang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442925/
https://www.ncbi.nlm.nih.gov/pubmed/36058938
http://dx.doi.org/10.1186/s12964-022-00837-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442925/
https://www.ncbi.nlm.nih.gov/pubmed/36058938
http://dx.doi.org/10.1186/s12964-022-00837-z

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