IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

BACKGROUND: IMI2-PainCare-BioPain-RCT2 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on specific compartments of the nociceptive system that could serve to accelerate the future development of analgesics. IMI2-PainCare-BioPain-R...

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Detalles Bibliográficos
Autores principales: Leone, Caterina, Di Stefano, Giulia, Di Pietro, Giuseppe, Bloms-Funke, Petra, Boesl, Irmgard, Caspani, Ombretta, Chapman, Sonya C., Finnerup, Nanna Brix, Garcia-Larrea, Luis, Li, Tom, Goetz, Marcus, Mouraux, André, Pelz, Bernhard, Pogatzki-Zahn, Esther, Schilder, Andreas, Schnetter, Erik, Schubart, Karin, Tracey, Irene, Troconiz, Inaki F., Van Niel, Hans, Hernandez, Jose Miguel Vela, Vincent, Katy, Vollert, Jan, Wanigasekera, Vishvarani, Wittayer, Matthias, Phillips, Keith G., Truini, Andrea, Treede, Rolf-Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442941/
https://www.ncbi.nlm.nih.gov/pubmed/36064434
http://dx.doi.org/10.1186/s13063-022-06431-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9442941/
https://www.ncbi.nlm.nih.gov/pubmed/36064434
http://dx.doi.org/10.1186/s13063-022-06431-5

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