Histologic description of acquired cholesteatomas: comparison between children and adults

Cholesteatoma is constituted of matrix, perimatrix and cystic content. Some authors affirm that, in children, its clinical behavior is more aggressive of the than in adults. AIMS: Histologic compared cholesteatomas of children and adults. METHODOLOGY: 74 cholesteatomas been analyzed, being 35 of ped...

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Autores principales: Dornelles, Cristina, Meurer, Luíse, da Costa, Sady Selaimen, Schweiger, Cláudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443531/
https://www.ncbi.nlm.nih.gov/pubmed/17221056
http://dx.doi.org/10.1016/S1808-8694(15)31020-X
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author Dornelles, Cristina
Meurer, Luíse
da Costa, Sady Selaimen
Schweiger, Cláudia
author_facet Dornelles, Cristina
Meurer, Luíse
da Costa, Sady Selaimen
Schweiger, Cláudia
author_sort Dornelles, Cristina
collection PubMed
description Cholesteatoma is constituted of matrix, perimatrix and cystic content. Some authors affirm that, in children, its clinical behavior is more aggressive of the than in adults. AIMS: Histologic compared cholesteatomas of children and adults. METHODOLOGY: 74 cholesteatomas been analyzed, being 35 of pediatrics patients (<18 years). The average number of cellular layers and hyperplasia in the matrix had been evaluated; thickness, delimitante epithelium, fibrosis, inflammation and granuloma in the perimatrix. The analysis statistics was carried through with program SPSS 10,0, using the coefficients of Pearson and Spearman, test of qui-square and t test. The number of cellular layers in the matrix was of 8,2±4,2. The hyperplasia appears in 17%, fibrosis in 65%, granuloma in 12% and the delimitante epithelium in 21%. The perimatrix presented a medium one of 80 micrometers (37 the 232), minimum value zero and maximum value 1.926. The histological degree of inflammation was considered of moderate the accented one in 60%. When applying the coefficient of Spearman enters the inflammation degree and average of cellular layers of the matrix with the variables of the measure of thickness of the perimatrix we find correlations, significant, with moderate magnitudes of the great ones (rs=0,5 and P<0,0001). CONCLUSION: Adults colesteatomas of and child had not been identified to morphologic differences between. We find correlation enters the intensity of the inflammation and of the average of cellular layers of the matrix with the thickness of the perimatrix, what it can predict its aggressiveness, more studies are necessary to define the paper of this finding in pathogenesis of cholesteatoma.
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spelling pubmed-94435312022-09-09 Histologic description of acquired cholesteatomas: comparison between children and adults Dornelles, Cristina Meurer, Luíse da Costa, Sady Selaimen Schweiger, Cláudia Braz J Otorhinolaryngol Original Article Cholesteatoma is constituted of matrix, perimatrix and cystic content. Some authors affirm that, in children, its clinical behavior is more aggressive of the than in adults. AIMS: Histologic compared cholesteatomas of children and adults. METHODOLOGY: 74 cholesteatomas been analyzed, being 35 of pediatrics patients (<18 years). The average number of cellular layers and hyperplasia in the matrix had been evaluated; thickness, delimitante epithelium, fibrosis, inflammation and granuloma in the perimatrix. The analysis statistics was carried through with program SPSS 10,0, using the coefficients of Pearson and Spearman, test of qui-square and t test. The number of cellular layers in the matrix was of 8,2±4,2. The hyperplasia appears in 17%, fibrosis in 65%, granuloma in 12% and the delimitante epithelium in 21%. The perimatrix presented a medium one of 80 micrometers (37 the 232), minimum value zero and maximum value 1.926. The histological degree of inflammation was considered of moderate the accented one in 60%. When applying the coefficient of Spearman enters the inflammation degree and average of cellular layers of the matrix with the variables of the measure of thickness of the perimatrix we find correlations, significant, with moderate magnitudes of the great ones (rs=0,5 and P<0,0001). CONCLUSION: Adults colesteatomas of and child had not been identified to morphologic differences between. We find correlation enters the intensity of the inflammation and of the average of cellular layers of the matrix with the thickness of the perimatrix, what it can predict its aggressiveness, more studies are necessary to define the paper of this finding in pathogenesis of cholesteatoma. Elsevier 2015-10-19 /pmc/articles/PMC9443531/ /pubmed/17221056 http://dx.doi.org/10.1016/S1808-8694(15)31020-X Text en . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Dornelles, Cristina
Meurer, Luíse
da Costa, Sady Selaimen
Schweiger, Cláudia
Histologic description of acquired cholesteatomas: comparison between children and adults
title Histologic description of acquired cholesteatomas: comparison between children and adults
title_full Histologic description of acquired cholesteatomas: comparison between children and adults
title_fullStr Histologic description of acquired cholesteatomas: comparison between children and adults
title_full_unstemmed Histologic description of acquired cholesteatomas: comparison between children and adults
title_short Histologic description of acquired cholesteatomas: comparison between children and adults
title_sort histologic description of acquired cholesteatomas: comparison between children and adults
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443531/
https://www.ncbi.nlm.nih.gov/pubmed/17221056
http://dx.doi.org/10.1016/S1808-8694(15)31020-X
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