Novel quinoxaline derivatives as dual EGFR and COX-2 inhibitors: synthesis, molecular docking and biological evaluation as potential anticancer and anti-inflammatory agents

Novel quinoxaline derivatives (2a–d, 3, 4a, 4b and 5–15) have been synthesized via the reaction of 4-methyl-3-oxo-3,4-dihydroquinoxaline-2-carbohydrazide (1) with different aldehydes, ketones, diketones, ketoesters, as well as hydrazine, phenyl isothiocyanate, carbon disulphide. The synthesized prod...

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Detalles Bibliográficos
Autores principales: Ahmed, Eman A., Mohamed, Mamdouh F. A., Omran, Omran A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443684/
https://www.ncbi.nlm.nih.gov/pubmed/36199335
http://dx.doi.org/10.1039/d2ra04498f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9443684/
https://www.ncbi.nlm.nih.gov/pubmed/36199335
http://dx.doi.org/10.1039/d2ra04498f

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