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Two-pore channels: going with the flows

In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P(2), TPCs are an integral part of fundamental signal-transduction pathways, but their array and plasti...

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Detalles Bibliográficos
Autores principales: Morgan, Anthony J., Martucci, Lora L., Davis, Lianne C., Galione, Antony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444070/
https://www.ncbi.nlm.nih.gov/pubmed/35959977
http://dx.doi.org/10.1042/BST20220229
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author Morgan, Anthony J.
Martucci, Lora L.
Davis, Lianne C.
Galione, Antony
author_facet Morgan, Anthony J.
Martucci, Lora L.
Davis, Lianne C.
Galione, Antony
author_sort Morgan, Anthony J.
collection PubMed
description In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P(2), TPCs are an integral part of fundamental signal-transduction pathways, but their array and plasticity of cation conductances (Na(+), Ca(2+), H(+)) allow them to variously signal electrically, osmotically or chemically. Their relative tissue- and organelle-selective distribution, together with agonist-selective ion permeabilities provides a rich palette from which extracellular stimuli can choose. TPCs are emerging as mediators of immunity, cancer, metabolism, viral infectivity and neurodegeneration as this short review attests.
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spelling pubmed-94440702022-09-07 Two-pore channels: going with the flows Morgan, Anthony J. Martucci, Lora L. Davis, Lianne C. Galione, Antony Biochem Soc Trans Review Articles In recent years, our understanding of the structure, mechanisms and functions of the endo-lysosomal TPC (two-pore channel) family have grown apace. Gated by the second messengers, NAADP and PI(3,5)P(2), TPCs are an integral part of fundamental signal-transduction pathways, but their array and plasticity of cation conductances (Na(+), Ca(2+), H(+)) allow them to variously signal electrically, osmotically or chemically. Their relative tissue- and organelle-selective distribution, together with agonist-selective ion permeabilities provides a rich palette from which extracellular stimuli can choose. TPCs are emerging as mediators of immunity, cancer, metabolism, viral infectivity and neurodegeneration as this short review attests. Portland Press Ltd. 2022-08-31 2022-08-12 /pmc/articles/PMC9444070/ /pubmed/35959977 http://dx.doi.org/10.1042/BST20220229 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Morgan, Anthony J.
Martucci, Lora L.
Davis, Lianne C.
Galione, Antony
Two-pore channels: going with the flows
title Two-pore channels: going with the flows
title_full Two-pore channels: going with the flows
title_fullStr Two-pore channels: going with the flows
title_full_unstemmed Two-pore channels: going with the flows
title_short Two-pore channels: going with the flows
title_sort two-pore channels: going with the flows
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444070/
https://www.ncbi.nlm.nih.gov/pubmed/35959977
http://dx.doi.org/10.1042/BST20220229
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