Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells

The protein kinases PAK4, PAK5 and PAK6 comprise a family of ohnologues. In multiple cancers including melanomas PAK5 most frequently carries non-synonymous mutations; PAK6 and PAK4 have fewer; and PAK4 is often amplified. To help interpret these genomic data, initially we compared the cellular regu...

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Detalles Bibliográficos
Autores principales: Murugesan, Gavuthami, Prescott, Alan R., Toth, Rachel, Campbell, David G., Wells, Claire M., MacKintosh, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444074/
https://www.ncbi.nlm.nih.gov/pubmed/35969127
http://dx.doi.org/10.1042/BCJ20220184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444074/
https://www.ncbi.nlm.nih.gov/pubmed/35969127
http://dx.doi.org/10.1042/BCJ20220184

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