SLC26A4 Mutation Promotes Cell Apoptosis by Inducing Pendrin Transfer, Reducing Cl(−) Transport, and Inhibiting PI3K/Akt/mTOR Pathway

OBJECTIVE: Pendrin is encoded by SLC26A4, which is expressed in the apical membrane of inner ear epithelial cells and drives chloride reabsorption in the apical septum. In the inner ear, pendrin dysfunction and hypofunctional mutations lead to vestibular aqueduct (EVA) enlargement and sensory neural...

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Detalles Bibliográficos
Autores principales: Dai, Xiang, Li, Jun, Hu, XiJiang, Ye, Jian, Cai, WenQian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444440/
https://www.ncbi.nlm.nih.gov/pubmed/36072472
http://dx.doi.org/10.1155/2022/6496799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444440/
https://www.ncbi.nlm.nih.gov/pubmed/36072472
http://dx.doi.org/10.1155/2022/6496799

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