Tyrosine phosphatase activity is restricted by basic charge substituting mutation of substrates

Phosphorylation controls important cellular signals and its dysregulation leads to disease. While most phospho-regulation studies are focused on kinases, phosphatases are comparatively overlooked. Combining peptide arrays with SAMDI mass spectrometry, we show that tyrosine phosphatase activity is re...

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Detalles Bibliográficos
Autores principales: Huang, Che-Fan, Gottardi, Cara J., Mrksich, Milan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445012/
https://www.ncbi.nlm.nih.gov/pubmed/36064958
http://dx.doi.org/10.1038/s41598-022-19133-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445012/
https://www.ncbi.nlm.nih.gov/pubmed/36064958
http://dx.doi.org/10.1038/s41598-022-19133-4

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