LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin

Clostridium novyi alpha-toxin (Tcnα) is a potent exotoxin that induces severe symptoms including gas gangrene, myositis, necrotic hepatitis, and sepsis. Tcnα binds to sulfated glycosaminoglycans (sGAG) for cell-surface attachment and utilizes low-density lipoprotein receptor (LDLR) for rapid entry....

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Detalles Bibliográficos
Autores principales: Zhou, Yao, Li, Danyang, Li, Diyin, Chen, Aizhong, He, Liuqing, Luo, Jianhua, Tao, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445046/
https://www.ncbi.nlm.nih.gov/pubmed/36064583
http://dx.doi.org/10.1038/s42003-022-03873-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445046/
https://www.ncbi.nlm.nih.gov/pubmed/36064583
http://dx.doi.org/10.1038/s42003-022-03873-0

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