Clonal dynamics underlying the skewed CD4/CD8 ratio of mouse thymocytes revealed by TCR-independent barcoding

T cell differentiation in the thymus generates CD4(+) helper and cytotoxic CD8(+) cells as the two principal T cell lineages. Curiously, at the end of this complex selection process, CD4(+) cells invariably outnumber CD8(+) cells. Here, we examine the dynamics of repertoire formation and the emergen...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwanami, Norimasa, Petersen, Malte, Diekhoff, Dagmar, Boehm, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445074/
https://www.ncbi.nlm.nih.gov/pubmed/36064961
http://dx.doi.org/10.1038/s42003-022-03870-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445074/
https://www.ncbi.nlm.nih.gov/pubmed/36064961
http://dx.doi.org/10.1038/s42003-022-03870-3

Ejemplares similares