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Clonal dynamics underlying the skewed CD4/CD8 ratio of mouse thymocytes revealed by TCR-independent barcoding

T cell differentiation in the thymus generates CD4(+) helper and cytotoxic CD8(+) cells as the two principal T cell lineages. Curiously, at the end of this complex selection process, CD4(+) cells invariably outnumber CD8(+) cells. Here, we examine the dynamics of repertoire formation and the emergen...

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Detalles Bibliográficos
Autores principales:	Iwanami, Norimasa, Petersen, Malte, Diekhoff, Dagmar, Boehm, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445074/ https://www.ncbi.nlm.nih.gov/pubmed/36064961 http://dx.doi.org/10.1038/s42003-022-03870-3

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