Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration

The trimeric serine protease HTRA1 is a genetic risk factor associated with geographic atrophy (GA), a currently untreatable form of age-related macular degeneration. Here, we describe the allosteric inhibition mechanism of HTRA1 by a clinical Fab fragment, currently being evaluated for GA treatment...

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Detalles Bibliográficos
Autores principales: Gerhardy, Stefan, Ultsch, Mark, Tang, Wanjian, Green, Evan, Holden, Jeffrey K., Li, Wei, Estevez, Alberto, Arthur, Chris, Tom, Irene, Rohou, Alexis, Kirchhofer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445180/
https://www.ncbi.nlm.nih.gov/pubmed/36064790
http://dx.doi.org/10.1038/s41467-022-32760-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445180/
https://www.ncbi.nlm.nih.gov/pubmed/36064790
http://dx.doi.org/10.1038/s41467-022-32760-9

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