Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status

OBJECTIVE: A major challenge in the treatment of platinum-resistant high-grade serous ovarian cancer (HGSOC) is lack of effective therapies. Much of ongoing research on drug candidates relies on HGSOC cell lines that are poorly documented. The goal of this study was to screen for effective, state-of...

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Detalles Bibliográficos
Autores principales: Roering, Pia, Siddiqui, Arafat, Heuser, Vanina D., Potdar, Swapnil, Mikkonen, Piia, Oikkonen, Jaana, Li, Yilin, Pikkusaari, Sanna, Wennerberg, Krister, Hynninen, Johanna, Grenman, Seija, Huhtinen, Kaisa, Auranen, Annika, Carpén, Olli, Kaipio, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445195/
https://www.ncbi.nlm.nih.gov/pubmed/36081565
http://dx.doi.org/10.3389/fonc.2022.954430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445195/
https://www.ncbi.nlm.nih.gov/pubmed/36081565
http://dx.doi.org/10.3389/fonc.2022.954430

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