Cargando…

Transcriptional bursts and heterogeneity among cardiomyocytes in hypertrophic cardiomyopathy

Transcriptional bursting is a common expression mode for most genes where independent transcription of alleles leads to different ratios of allelic mRNA from cell to cell. Here we investigated burst-like transcription and its consequences in cardiac tissue from Hypertrophic Cardiomyopathy (HCM) pati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burkart, Valentin, Kowalski, Kathrin, Aldag-Niebling, David, Beck, Julia, Frick, Dirk Alexander, Holler, Tim, Radocaj, Ante, Piep, Birgit, Zeug, Andre, Hilfiker-Kleiner, Denise, dos Remedios, Cristobal G., van der Velden, Jolanda, Montag, Judith, Kraft, Theresia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445301/ https://www.ncbi.nlm.nih.gov/pubmed/36082122 http://dx.doi.org/10.3389/fcvm.2022.987889

Ejemplares similares

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy
por: Montag, Judith, et al.
Publicado: (2018)

AQUA Mutant Protein Quantification of Endomyocardial Biopsy-Sized Samples From a Patient With Hypertrophic Cardiomyopathy
por: Becker, Edgar, et al.
Publicado: (2022)

Familial hypertrophic cardiomyopathy: functional variance among individual cardiomyocytes as a trigger of FHC-phenotype development
por: Brenner, Bernhard, et al.
Publicado: (2014)

Advanced Single-Cell Mapping Reveals that in hESC Cardiomyocytes Contraction Kinetics and Action Potential Are Independent of Myosin Isoform
por: Weber, Natalie, et al.
Publicado: (2020)

Stochastic allelic expression as trigger for contractile imbalance in hypertrophic cardiomyopathy
por: Montag, Judith, et al.
Publicado: (2020)

Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms
por: Iorga, Bogdan, et al.
Publicado: (2018)

Altered force generation and cell-to-cell contractile imbalance in hypertrophic cardiomyopathy
por: Kraft, Theresia, et al.
Publicado: (2019)

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy
por: Montag, Judith, et al.
Publicado: (2017)

Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy
por: Dorsch, Larissa M., et al.
Publicado: (2019)

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy
por: McNamara, James W., et al.
Publicado: (2017)

Scientists on the spot: Relaxing the heart in hypertrophic cardiomyopathy
por: Gladka, Monika M, et al.
Publicado: (2023)

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology
por: van der Velden, Jolanda, et al.
Publicado: (2018)

Blood-based protein profiling identifies serum protein c-KIT as a novel biomarker for hypertrophic cardiomyopathy
por: Sonnenschein, Kristina, et al.
Publicado: (2021)

Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot, and its functional evaluation in the Drosophila heart
por: Auxerre-Plantié, Emilie, et al.
Publicado: (2020)

Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy
por: Nijenkamp, Louise L. A. M., et al.
Publicado: (2020)

Unequal allelic expression of wild-type and mutated β-myosin in familial hypertrophic cardiomyopathy
por: Tripathi, Snigdha, et al.
Publicado: (2011)

Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration
por: Nollet, Edgar E, et al.
Publicado: (2023)

Integrins Are the Necessary Links to Hypertrophic Growth in Cardiomyocytes
por: Harston, Rebecca K., et al.
Publicado: (2011)

Sex-Related Differences in Protein Expression in Sarcomere Mutation-Positive Hypertrophic Cardiomyopathy
por: Schuldt, Maike, et al.
Publicado: (2021)

Hypertrophic Cardiomyopathy in Infants from the Perspective of Cardiomyocyte Maturation
por: Seok, Heeyoung, et al.
Publicado: (2021)

Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages
por: Heimerl, Maren, et al.
Publicado: (2020)

Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes
por: Ramachandra, Chrishan J A, et al.
Publicado: (2021)

Hypertrophic Stimulation Increases β-actin Dynamics in Adult Feline Cardiomyocytes
por: Balasubramanian, Sundaravadivel, et al.
Publicado: (2010)

Corrigendum to: Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes
Publicado: (2021)

Cardiomyocytes display low mitochondrial priming and are highly resistant toward cytotoxic T‐cell killing
por: Zheng, Xiang, et al.
Publicado: (2016)

Cycling Cross-Bridges Contribute to Thin Filament Activation in Human Slow-Twitch Fibers
por: López-Dávila, Alfredo Jesus, et al.
Publicado: (2020)

Efficient Knock-in of a Point Mutation in Porcine Fibroblasts Using the CRISPR/Cas9-GMNN Fusion Gene
por: Gerlach, Max, et al.
Publicado: (2018)

Regional myocardial function at preclinical disease stage of hypertrophic cardiomyopathy in female gene variant carriers
por: Parbhudayal, Rahana Y., et al.
Publicado: (2021)

The effect of inhibition of the Na(+)/H(+) exchanger on the development of hypertrophy in hypertrophic cardiomyopathy
por: Brouwer, Wessel P, et al.
Publicado: (2011)

Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy
por: Bollen, Ilse A. E., et al.
Publicado: (2017)

Human iPSC-Derived Cardiomyocytes of Peripartum Patients With Cardiomyopathy Reveal Aberrant Regulation of Lipid Metabolism
por: Hoes, Martijn F., et al.
Publicado: (2020)

Blinding integrity of dorsomedial prefrontal intermittent theta burst stimulation in depression
por: Bengtsson, Johan, et al.
Publicado: (2023)

Alteration in mitochondrial Ca(2+) uptake disrupts insulin signaling in hypertrophic cardiomyocytes
por: Gutiérrez, Tomás, et al.
Publicado: (2014)

Effect of puerarin on action potential and sodium channel activation in human hypertrophic cardiomyocytes
por: Lin, Yu-hui, et al.
Publicado: (2020)

Changes in Cardiomyocyte Cell Cycle and Hypertrophic Growth During Fetal to Adult in Mammals
por: Bishop, Sanford P., et al.
Publicado: (2021)

Gene expression profiling of hypertrophic cardiomyocytes identifies new players in pathological remodelling
por: Vigil-Garcia, Marta, et al.
Publicado: (2020)

Extracellular SPARC increases cardiomyocyte contraction during health and disease
por: Deckx, Sophie, et al.
Publicado: (2019)

Unraveling the Genotype‐Phenotype Relationship in Hypertrophic Cardiomyopathy: Obesity‐Related Cardiac Defects as a Major Disease Modifier
por: Nollet, Edgar E., et al.
Publicado: (2020)

Mimicking the cardiac cycle in intact cardiomyocytes using diastolic and systolic force clamps; measuring power output
por: Helmes, Michiel, et al.
Publicado: (2016)

Increased Myocardial Oxygen Consumption Precedes Contractile Dysfunction in Hypertrophic Cardiomyopathy Caused by Pathogenic TNNT2 Gene Variants
por: Parbhudayal, Rahana Y., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_f5mp4cmjqhufr4ckja9btg9qs8