Characterization of MET Exon 14 Skipping Alterations (in NSCLC) and Identification of Potential Therapeutic Targets Using Whole Transcriptome Sequencing

INTRODUCTION: Genomic alterations in the juxtamembrane exon 14 splice sites in NSCLC lead to increased MET stability and oncogenesis. We present the largest cohort study of MET Exon 14 (METex14) using whole transcriptome sequencing. METHODS: A total of 21,582 NSCLC tumor samples underwent complete g...

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Detalles Bibliográficos
Autores principales: Kim, So Yeon, Yin, Jun, Bohlman, Stephen, Walker, Phillip, Dacic, Sanja, Kim, Chul, Khan, Hina, Liu, Stephen V., Ma, Patrick C., Nagasaka, Misako, Reckamp, Karen L., Abraham, Jim, Uprety, Dipesh, Wang, Feng, Xiu, Joanne, Zhang, Jian, Cheng, Haiying, Halmos, Balazs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445394/
https://www.ncbi.nlm.nih.gov/pubmed/36082279
http://dx.doi.org/10.1016/j.jtocrr.2022.100381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445394/
https://www.ncbi.nlm.nih.gov/pubmed/36082279
http://dx.doi.org/10.1016/j.jtocrr.2022.100381

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