Oncogenic fusion of BCAR4 activates EGFR signaling and is sensitive to dual inhibition of EGFR/HER2

We previously reported CD63-BCAR4 fusion as a novel oncogene that significantly enhanced cell migration and metastasis in lung cancer. To identify effective inhibitors of metastatic activity induced by BCAR4 fusion, we screened a drug library of 381 FDA-approved compounds. The effect of drugs on cel...

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Detalles Bibliográficos
Autores principales: Bae, Kieun, Kim, Jin Hee, Lee, Ja Young, Kong, Sun-Young, Kim, Yun-Hee, Kim, Sunshin, Yoon, Kyong-Ah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445485/
https://www.ncbi.nlm.nih.gov/pubmed/36081848
http://dx.doi.org/10.3389/fmolb.2022.952651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9445485/
https://www.ncbi.nlm.nih.gov/pubmed/36081848
http://dx.doi.org/10.3389/fmolb.2022.952651

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