Unraveling the Pivotal Role of Atropisomerism for Cellular Internalization

[Image: see text] The intrinsic challenge of large molecules to cross the cell membrane and reach intracellular targets is a major obstacle for the development of new medicines. We report how rotation along a single C–C bond, between atropisomers of a drug in clinical trials, improves cell uptake an...

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Detalles Bibliográficos
Autores principales: Donohoe, Claire, Schaberle, Fábio A., Rodrigues, Fábio M. S., Gonçalves, Nuno P. F., Kingsbury, Christopher J., Pereira, Mariette M., Senge, Mathias O., Gomes-da-Silva, Lígia C., Arnaut, Luis G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446767/
https://www.ncbi.nlm.nih.gov/pubmed/35960892
http://dx.doi.org/10.1021/jacs.2c05844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446767/
https://www.ncbi.nlm.nih.gov/pubmed/35960892
http://dx.doi.org/10.1021/jacs.2c05844

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