Preparation of a camptothecin analog FLQY2 self-micelle solid dispersion with improved solubility and bioavailability

BACKGROUND: 7-p-trifluoromethylphenyl-FL118 (FLQY2) is a camptothecin analog with excellent antitumor efficacy against various solid tumors. However, its poor solubility and low bioavailability limited the development of the drug. Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft cop...

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Detalles Bibliográficos
Autores principales: Wang, Yi, Wang, Wenchao, Yu, Endian, Zhuang, Wenya, Sun, Xuanrong, Wang, Hong, Li, Qingyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446799/
https://www.ncbi.nlm.nih.gov/pubmed/36064403
http://dx.doi.org/10.1186/s12951-022-01596-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446799/
https://www.ncbi.nlm.nih.gov/pubmed/36064403
http://dx.doi.org/10.1186/s12951-022-01596-2

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