Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia

Excessive hepatic glucose production contributes to the development of hyperglycemia and is a key feature of type 2 diabetes. Here, we report that activation of hepatocyte Rap1a suppresses gluconeogenic gene expression and glucose production, whereas Rap1a silencing stimulates them. Rap1a activation...

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Detalles Bibliográficos
Autores principales: Wang, Yating, Spolitu, Stefano, Zadroga, John A., Sarecha, Amesh K., Ozcan, Lale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446800/
https://www.ncbi.nlm.nih.gov/pubmed/36001955
http://dx.doi.org/10.1016/j.celrep.2022.111259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446800/
https://www.ncbi.nlm.nih.gov/pubmed/36001955
http://dx.doi.org/10.1016/j.celrep.2022.111259

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