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Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
Excessive hepatic glucose production contributes to the development of hyperglycemia and is a key feature of type 2 diabetes. Here, we report that activation of hepatocyte Rap1a suppresses gluconeogenic gene expression and glucose production, whereas Rap1a silencing stimulates them. Rap1a activation...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446800/ https://www.ncbi.nlm.nih.gov/pubmed/36001955 http://dx.doi.org/10.1016/j.celrep.2022.111259 |