Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells

BACKGROUND: We previously reported higher plasma levels of complement fragments C3a and C5a in neovascular Age-related Macular Degeneration (nAMD) patients with macular fibrosis. This study aimed to understand whether complement activation contributes to the development of macular fibrosis and the u...

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Detalles Bibliográficos
Autores principales: Llorián-Salvador, María, Byrne, Eimear M., Szczepan, Manon, Little, Karis, Chen, Mei, Xu, Heping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9447479/
https://www.ncbi.nlm.nih.gov/pubmed/35831910
http://dx.doi.org/10.1186/s12974-022-02546-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9447479/
https://www.ncbi.nlm.nih.gov/pubmed/35831910
http://dx.doi.org/10.1186/s12974-022-02546-3

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