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Fitness Landscape Analysis of a tRNA Gene Reveals that the Wild Type Allele is Sub-optimal, Yet Mutationally Robust

Fitness landscape mapping and the prediction of evolutionary trajectories on these landscapes are major tasks in evolutionary biology research. Evolutionary dynamics is tightly linked to the landscape topography, but this relation is not straightforward. Here, we analyze a fitness landscape of a yea...

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Detalles Bibliográficos
Autores principales: Gabzi, Tzahi, Pilpel, Yitzhak, Friedlander, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9447856/
https://www.ncbi.nlm.nih.gov/pubmed/35976926
http://dx.doi.org/10.1093/molbev/msac178