Fluorosulfate-containing pyrazole heterocycles as selective BuChE inhibitors: structure-activity relationship and biological evaluation for the treatment of Alzheimer’s disease

Novel scaffolds are expected to treat Alzheimer’s disease, pyrazole-5-fluorosulfates were found as selective BuChE inhibitors. Compounds K1–K26 were assayed for ChE inhibitory activity, amongst them, compound K3 showed potent BuChE and hBuChE inhibition (IC(50) = 0.79 μM and 6.59 μM). SAR analysis s...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Huan-Huan, Wu, Chengyao, Zhang, Shi-Long, Yang, Jian-Guo, Qin, Hua-Li, Tang, Wenjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448382/
https://www.ncbi.nlm.nih.gov/pubmed/35899776
http://dx.doi.org/10.1080/14756366.2022.2103553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448382/
https://www.ncbi.nlm.nih.gov/pubmed/35899776
http://dx.doi.org/10.1080/14756366.2022.2103553

Ejemplares similares