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Lysosome Inhibition Reduces Basal and Nutrient-Induced Fat Accumulation in Caenorhabditis elegans

A long-term energy nutritional imbalance fundamentally causes the development of obesity and associated fat accumulation. Lysosomes, as nutrient-sensing and lipophagy centers, critically control cellular lipid catabolism in response to nutrient deprivation. However, whether lysosome activity is dire...

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Detalles Bibliográficos
Autores principales: Lu, Rui, Chen, Juan, Wang, Fangbin, Wang, Lu, Liu, Jian, Lin, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448645/
https://www.ncbi.nlm.nih.gov/pubmed/36058890
http://dx.doi.org/10.14348/molcells.2022.0073