Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury

Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase that interacts with WD repeat domain 5 (WDR5) to regulate cell survival, proliferation, and senescence. The role of MLL1 in the pathogenesis of acute kidney injury (AKI) is unknown. In this study, we demonstrate that M...

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Detalles Bibliográficos
Autores principales: Zhang, Chunyun, Guan, Yingjie, Zou, Jianan, Yang, Xu, Bayliss, Georgia, Zhuang, Shougang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448773/
https://www.ncbi.nlm.nih.gov/pubmed/36068197
http://dx.doi.org/10.1038/s41419-022-05104-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448773/
https://www.ncbi.nlm.nih.gov/pubmed/36068197
http://dx.doi.org/10.1038/s41419-022-05104-0

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