Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis

Enzymes with high activity are readily produced through protein engineering, but intentionally and efficiently engineering enzymes for an expanded substrate scope is a contemporary challenge. One approach to address this challenge is Substrate Multiplexed Screening (SUMS), where enzyme activity is m...

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Detalles Bibliográficos
Autores principales: McDonald, Allwin D., Higgins, Peyton M., Buller, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448781/
https://www.ncbi.nlm.nih.gov/pubmed/36068220
http://dx.doi.org/10.1038/s41467-022-32789-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448781/
https://www.ncbi.nlm.nih.gov/pubmed/36068220
http://dx.doi.org/10.1038/s41467-022-32789-w

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