UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression

Loss-of-function mutations at the retinoblastoma (RB1) gene are associated with increased mortality, metastasis, and poor therapeutic outcome in several cancers, including osteosarcoma. However, the mechanism(s) through which RB1 loss worsens clinical outcome remains understudied. Ubiquitin-like wit...

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Detalles Bibliográficos
Autores principales: Wu, Stephanie C., Kim, Ahhyun, Gu, Yijun, Martinez, Daniel I., Zocchi, Loredana, Chen, Claire C., Lopez, Jocelyne, Salcido, Kelsey, Singh, Sarah, Wu, Jie, Nael, Ali, Benavente, Claudia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448786/
https://www.ncbi.nlm.nih.gov/pubmed/36068209
http://dx.doi.org/10.1038/s41389-022-00430-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448786/
https://www.ncbi.nlm.nih.gov/pubmed/36068209
http://dx.doi.org/10.1038/s41389-022-00430-6

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