Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression

The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic kidney disease leads to proximal tubule injury and changes in chromatin accessibility that modify the activity of transcription factors involved in glucose metabolism and inflammation. Here we use single nucle...

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Detalles Bibliográficos
Autores principales: Wilson, Parker C., Muto, Yoshiharu, Wu, Haojia, Karihaloo, Anil, Waikar, Sushrut S., Humphreys, Benjamin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448792/
https://www.ncbi.nlm.nih.gov/pubmed/36068241
http://dx.doi.org/10.1038/s41467-022-32972-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448792/
https://www.ncbi.nlm.nih.gov/pubmed/36068241
http://dx.doi.org/10.1038/s41467-022-32972-z

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