Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: results from the CAN-BIND 1 study

Cytochrome P450 drug-metabolizing enzymes may contribute to interindividual differences in antidepressant outcomes. We investigated the effects of CYP2C19 and CYP2D6 gene variants on response, tolerability, and serum concentrations. Patients (N = 178) were treated with escitalopram (ESC) from weeks...

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Detalles Bibliográficos
Autores principales: Islam, Farhana, Marshe, Victoria S., Magarbeh, Leen, Frey, Benicio N., Milev, Roumen V., Soares, Claudio N., Parikh, Sagar V., Placenza, Franca, Strother, Stephen C., Hassel, Stefanie, Taylor, Valerie H., Leri, Francesco, Blier, Pierre, Uher, Rudolf, Farzan, Faranak, Lam, Raymond W., Turecki, Gustavo, Foster, Jane A., Rotzinger, Susan, Kennedy, Sidney H., Müller, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448818/
https://www.ncbi.nlm.nih.gov/pubmed/36068210
http://dx.doi.org/10.1038/s41398-022-02124-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9448818/
https://www.ncbi.nlm.nih.gov/pubmed/36068210
http://dx.doi.org/10.1038/s41398-022-02124-4

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