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Platelets correlate with false negative T-SPOT.TB results by inhibiting interferon-γ production in T cells via degranulation
BACKGROUND: T-SPOT.TB (T-SPOT) is widely used for the detection of Mycobacterium tuberculosis infection by detecting interferon-gamma (IFN-γ) release in T lymphocytes. This assay is performed on peripheral blood mononuclear cells (PBMCs) separated by Ficoll density gradient centrifugation, which oft...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449319/ https://www.ncbi.nlm.nih.gov/pubmed/36093183 http://dx.doi.org/10.3389/fcimb.2022.937416 |