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Platelets correlate with false negative T-SPOT.TB results by inhibiting interferon-γ production in T cells via degranulation

BACKGROUND: T-SPOT.TB (T-SPOT) is widely used for the detection of Mycobacterium tuberculosis infection by detecting interferon-gamma (IFN-γ) release in T lymphocytes. This assay is performed on peripheral blood mononuclear cells (PBMCs) separated by Ficoll density gradient centrifugation, which oft...

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Detalles Bibliográficos
Autores principales:	Rao, Jiayue, Rao, Yuting, Guo, Yang, Jiang, Mei, Long, Dan, Luo, Qing, Huang, Zikun, Li, Junming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449319/ https://www.ncbi.nlm.nih.gov/pubmed/36093183 http://dx.doi.org/10.3389/fcimb.2022.937416

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