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BMS‐202, a PD‐1/PD‐L1 inhibitor, decelerates the pro‑fibrotic effects of fibroblasts derived from scar tissues via ERK and TGFβ1/Smad signaling pathways
INTRODUCTION: Hypertrophic scar (HS), a fibroproliferative disorder of the skin with some tumor‐like properties, is closely related to dysregulated inflammation. PD‐1/PD‐L1 inhibitor is a promising medication for cancer therapy as its potent functions on adaptive immune response; whether it could be...
Autores principales: | Cai, Yuanyuan, Xiao, Min, Li, Xinqing, Zhou, Shanyu, Sun, Yangyang, Yu, Wenyuan, Zhao, Tianlan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449589/ https://www.ncbi.nlm.nih.gov/pubmed/36169254 http://dx.doi.org/10.1002/iid3.693 |
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