An expression-based variant impact phenotyping protocol to predict the impact of gene variants in cell lines

We describe a bioinformatics protocol for eVIP2 (expression-based variant impact phenotyping). eVIP2 can predict a gene variant’s functional impact by comparing gene expression signatures induced by introduction of wild-type versus mutant cDNAs in cell lines. The predicted functional outcomes of the...

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Detalles Bibliográficos
Autores principales: Thornton, Alexis M., Tumu, Manoj, Brooks, Angela N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449654/
https://www.ncbi.nlm.nih.gov/pubmed/36092819
http://dx.doi.org/10.1016/j.xpro.2022.101651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449654/
https://www.ncbi.nlm.nih.gov/pubmed/36092819
http://dx.doi.org/10.1016/j.xpro.2022.101651

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