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An expression-based variant impact phenotyping protocol to predict the impact of gene variants in cell lines
We describe a bioinformatics protocol for eVIP2 (expression-based variant impact phenotyping). eVIP2 can predict a gene variant’s functional impact by comparing gene expression signatures induced by introduction of wild-type versus mutant cDNAs in cell lines. The predicted functional outcomes of the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449654/ https://www.ncbi.nlm.nih.gov/pubmed/36092819 http://dx.doi.org/10.1016/j.xpro.2022.101651 |