Pamoic acid is an inhibitor of HMGB1·CXCL12 elicited chemotaxis and reduces inflammation in murine models of Pseudomonas aeruginosa pneumonia

BACKGROUND: High-mobility group box 1 protein (HMGB1) is an ubiquitous nuclear protein that once released in the extracellular space acts as a Damage Associated Molecular Pattern and promotes inflammation. HMGB1 is significantly elevated during Pseudomonas aeruginosa infections and has a clinical re...

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Detalles Bibliográficos
Autores principales: De Leo, Federica, Rossi, Alice, De Marchis, Francesco, Cigana, Cristina, Melessike, Medede, Quilici, Giacomo, De Fino, Ida, Mantonico, Malisa Vittoria, Fabris, Chantal, Bragonzi, Alessandra, Bianchi, Marco Emilio, Musco, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449960/
https://www.ncbi.nlm.nih.gov/pubmed/36071400
http://dx.doi.org/10.1186/s10020-022-00535-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449960/
https://www.ncbi.nlm.nih.gov/pubmed/36071400
http://dx.doi.org/10.1186/s10020-022-00535-z

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