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Pamoic acid is an inhibitor of HMGB1·CXCL12 elicited chemotaxis and reduces inflammation in murine models of Pseudomonas aeruginosa pneumonia
BACKGROUND: High-mobility group box 1 protein (HMGB1) is an ubiquitous nuclear protein that once released in the extracellular space acts as a Damage Associated Molecular Pattern and promotes inflammation. HMGB1 is significantly elevated during Pseudomonas aeruginosa infections and has a clinical re...
Autores principales: | De Leo, Federica, Rossi, Alice, De Marchis, Francesco, Cigana, Cristina, Melessike, Medede, Quilici, Giacomo, De Fino, Ida, Mantonico, Malisa Vittoria, Fabris, Chantal, Bragonzi, Alessandra, Bianchi, Marco Emilio, Musco, Giovanna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449960/ https://www.ncbi.nlm.nih.gov/pubmed/36071400 http://dx.doi.org/10.1186/s10020-022-00535-z |
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