NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF

[Image: see text] Structure–function relationships in proteins refer to a trade-off between stability and bioactivity, molded by evolution of the molecule. Identifying which protein amino acid residues jeopardize global or local stability for the benefit of bioactivity would reveal residues pivotal...

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Detalles Bibliográficos
Autores principales: Kellerman, Mark-Adam W., Almeida, Teresa, Rudd, Timothy R., Matejtschuk, Paul, Dalby, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449972/
https://www.ncbi.nlm.nih.gov/pubmed/35948076
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449972/
https://www.ncbi.nlm.nih.gov/pubmed/35948076
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00398

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