Cargando…
NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF
[Image: see text] Structure–function relationships in proteins refer to a trade-off between stability and bioactivity, molded by evolution of the molecule. Identifying which protein amino acid residues jeopardize global or local stability for the benefit of bioactivity would reveal residues pivotal...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449972/ https://www.ncbi.nlm.nih.gov/pubmed/35948076 http://dx.doi.org/10.1021/acs.molpharmaceut.2c00398 |