Understanding the Stabilizing Effect of Histidine on mAb Aggregation: A Molecular Dynamics Study

[Image: see text] Histidine, a widely used buffer in monoclonal antibody (mAb) formulations, is known to reduce antibody aggregation. While experimental studies suggest a nonelectrostatic, nonstructural (relating to secondary structure preservation) origin of the phenomenon, the underlying microscop...

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Detalles Bibliográficos
Autores principales: Saurabh, Suman, Kalonia, Cavan, Li, Zongyi, Hollowell, Peter, Waigh, Thomas, Li, Peixun, Webster, John, Seddon, John M., Lu, Jian R., Bresme, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449975/
https://www.ncbi.nlm.nih.gov/pubmed/35946408
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449975/
https://www.ncbi.nlm.nih.gov/pubmed/35946408
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00453

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