Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias

Within the intestine, the human G protein–coupled receptor (GPCR) GPR35 is involved in oncogenic signaling, bacterial infections, and inflammatory bowel disease. GPR35 is known to be expressed as two distinct isoforms that differ only in the length of their extracellular N-termini by 31 amino acids,...

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Detalles Bibliográficos
Autores principales: Schihada, Hannes, Klompstra, Thomas M., Humphrys, Laura J., Cervenka, Igor, Dadvar, Shamim, Kolb, Peter, Ruas, Jorge L., Schulte, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450150/
https://www.ncbi.nlm.nih.gov/pubmed/35933013
http://dx.doi.org/10.1016/j.jbc.2022.102328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450150/
https://www.ncbi.nlm.nih.gov/pubmed/35933013
http://dx.doi.org/10.1016/j.jbc.2022.102328

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