Cargando…

TMBur: a distributable tumor mutation burden approach for whole genome sequencing

BACKGROUND: Tumor mutation burden (TMB) is a key characteristic used in a tumor-type agnostic context to inform the use of immune checkpoint inhibitors (ICI). Accurate and consistent measurement of TMB is crucial as it can significantly impact patient selection for therapy and clinical trials, with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Titmuss, Emma, Corbett, Richard D., Davidson, Scott, Abbasi, Sanna, Williamson, Laura M., Pleasance, Erin D., Shlien, Adam, Renouf, Daniel J., Jones, Steven J. M., Laskin, Janessa, Marra, Marco A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450342/ https://www.ncbi.nlm.nih.gov/pubmed/36071521 http://dx.doi.org/10.1186/s12920-022-01348-z

Ejemplares similares

Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy
por: Zhang, Yiqun, et al.
Publicado: (2021)

Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic DPYD structural variant
por: Majounie, Elisa, et al.
Publicado: (2020)

Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration
por: Tsang, Erica S., et al.
Publicado: (2023)

Clinical and cost outcomes following genomics‐informed treatment for advanced cancers
por: Weymann, Deirdre, et al.
Publicado: (2021)

Whole-genome and transcriptome analysis of advanced adrenocortical cancer highlights multiple alterations affecting epigenome and DNA repair pathways
por: Lavoie, Jean-Michel, et al.
Publicado: (2022)

Clinical outcomes after whole-genome sequencing in patients with metastatic non-small-cell lung cancer
por: Tsang, Erica S., et al.
Publicado: (2019)

Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making
por: Chahal, Manik, et al.
Publicado: (2018)

Molecular etiology of an indolent lymphoproliferative disorder determined by whole-genome sequencing
por: Parker, Jeremy D.K., et al.
Publicado: (2016)

Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury
por: Williamson, Laura M., et al.
Publicado: (2021)

The cost and cost trajectory of whole‐genome analysis guiding treatment of patients with advanced cancers
por: Weymann, Deirdre, et al.
Publicado: (2017)

Establishing a Framework for the Clinical Translation of Germline Findings in Precision Oncology
por: Dixon, Katherine, et al.
Publicado: (2020)

The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system
por: Wong, Derek, et al.
Publicado: (2019)

Application of a Neural Network Whole Transcriptome–Based Pan-Cancer Method for Diagnosis of Primary and Metastatic Cancers
por: Grewal, Jasleen K., et al.
Publicado: (2019)

Personalized Oncogenomics: Clinical Experience with Malignant Peritoneal Mesothelioma Using Whole Genome Sequencing
por: Sheffield, Brandon S., et al.
Publicado: (2015)

Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma
por: Thibodeau, My Linh, et al.
Publicado: (2018)

Matching methods in precision oncology: An introduction and illustrative example
por: Weymann, Deirdre, et al.
Publicado: (2020)

Lessons learned from the application of whole-genome analysis to the treatment of patients with advanced cancers
por: Laskin, Janessa, et al.
Publicado: (2015)

Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers
por: Romero, Joan Miguel, et al.
Publicado: (2023)

Early-stage economic analysis of research-based comprehensive genomic sequencing for advanced cancer care
por: Weymann, Deirdre, et al.
Publicado: (2021)

NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling
por: Britton, Heidi M., et al.
Publicado: (2021)

Immune Activation following Irbesartan Treatment in a Colorectal Cancer Patient: A Case Study
por: Titmuss, E., et al.
Publicado: (2023)

Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing
por: Wong, Hui-li, et al.
Publicado: (2018)

Improved structural variant interpretation for hereditary cancer susceptibility using long-read sequencing
por: Thibodeau, My Linh, et al.
Publicado: (2020)

Molecular characterization of ERBB2-amplified colorectal cancer identifies potential mechanisms of resistance to targeted therapies: a report of two instructive cases
por: Owen, Daniel R., et al.
Publicado: (2018)

Whole-genome and transcriptome profiling of a metastatic thyroid-like follicular renal cell carcinoma
por: Ko, Jenny J., et al.
Publicado: (2018)

Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer
por: Jones, M. R., et al.
Publicado: (2016)

Genomic characterization of a well-differentiated grade 3 pancreatic neuroendocrine tumor
por: Williamson, Laura M., et al.
Publicado: (2019)

The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies
por: Tessier‐Cloutier, Basile, et al.
Publicado: (2022)

Tumor infiltrating neutrophils and gland formation predict overall survival and molecular subgroups in pancreatic ductal adenocarcinoma
por: Naso, Julia R., et al.
Publicado: (2020)

Knowledge, attitudes, and values among physicians working with clinical genomics: a survey of medical oncologists
por: Chow-White, Peter, et al.
Publicado: (2017)

A platform for oncogenomic reporting and interpretation
por: Reisle, Caralyn, et al.
Publicado: (2022)

Locally Advanced Cutaneous Squamous Cell Carcinoma: Two Case Reports of Dramatic Responses to Sequential Cisplatin, Docetaxel and Radiotherapy
por: Dennis, Kristopher E., et al.
Publicado: (2011)

A retrospective review of the multidisciplinary management of medullary thyroid cancer: eligibility for systemic therapy
por: Geller, Georgia, et al.
Publicado: (2017)

Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma
por: Topham, James T., et al.
Publicado: (2022)

A Distributed Whole Genome Sequencing Benchmark Study
por: Corbett, Richard D., et al.
Publicado: (2020)

Base excision repair deficiency signatures implicate germline and somatic MUTYH aberrations in pancreatic ductal adenocarcinoma and breast cancer oncogenesis
por: Thibodeau, My Linh, et al.
Publicado: (2019)

A p53 transcriptional signature in primary and metastatic cancers derived using machine learning
por: Keshavarz-Rahaghi, Faeze, et al.
Publicado: (2022)

The global distribution and burden of dengue
por: Bhatt, Samir, et al.
Publicado: (2013)

The Geographical Distribution and Burden of Trachoma in Africa
por: Smith, Jennifer L., et al.
Publicado: (2013)

Predicted distribution and burden of podoconiosis in Cameroon
por: Deribe, Kebede, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2nhuhnmc08pf2nu4vt3msaqs5f