Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomes

Shortly after the onset of the COVID-19 pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has acquired numerous variations in its intracellular proteins to adapt quickly, become more infectious, and ultimately develop drug resistance by mutating certain hotspot residues. To keep...

Descripción completa

Detalles Bibliográficos
Autores principales: Padhi, Aditya K., Tripathi, Timir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450486/
https://www.ncbi.nlm.nih.gov/pubmed/36113178
http://dx.doi.org/10.1016/j.bbrc.2022.09.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450486/
https://www.ncbi.nlm.nih.gov/pubmed/36113178
http://dx.doi.org/10.1016/j.bbrc.2022.09.010

Ejemplares similares