Hydroxychloroquine Attenuates Myocardial Ischemic and Post-Ischemic Reperfusion Injury by Inhibiting the Toll-Like Receptor 9 – Type I Interferon Pathway

BACKGROUND: We hypothesized that hydroxychloroquine (HCQ) attenuates myocardial ischemia/reperfusion injury (IRI) via TLR9 – type I interferon (IFN-I) pathway inhibition. METHODS: The left coronary artery of wild-type (WT) C57BL/6 and congenic TLR9(−/−) mice was occluded for 40 minutes, with or with...

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Detalles Bibliográficos
Autores principales: Marsh, Katherine M, Rastogi, Radhika, Zhang, Aimee, Wu, Di, Kron, Irving L, Yang, Zequan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450995/
https://www.ncbi.nlm.nih.gov/pubmed/36081846
http://dx.doi.org/10.26502/fccm.92920278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450995/
https://www.ncbi.nlm.nih.gov/pubmed/36081846
http://dx.doi.org/10.26502/fccm.92920278

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