A two-step mechanism governing PARP1-DNA retention by PARP inhibitors

PARP inhibitors (PARPi) have emerged as promising cancer therapeutics capable of targeting specific DNA repair pathways, but their mechanism of action with respect to PARP1-DNA retention remains unclear. Here, we developed single-molecule assays to directly monitor the retention of PARP1 on DNA lesi...

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Detalles Bibliográficos
Autores principales: Xue, Huijun, Bhardwaj, Amit, Yin, Yandong, Fijen, Carel, Ephstein, Anastasiya, Zhang, Lianglin, Ding, Xia, Pascal, John M., VanArsdale, Todd L., Rothenberg, Eli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451145/
https://www.ncbi.nlm.nih.gov/pubmed/36070389
http://dx.doi.org/10.1126/sciadv.abq0414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451145/
https://www.ncbi.nlm.nih.gov/pubmed/36070389
http://dx.doi.org/10.1126/sciadv.abq0414

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