Cargando…

A two-step mechanism governing PARP1-DNA retention by PARP inhibitors

PARP inhibitors (PARPi) have emerged as promising cancer therapeutics capable of targeting specific DNA repair pathways, but their mechanism of action with respect to PARP1-DNA retention remains unclear. Here, we developed single-molecule assays to directly monitor the retention of PARP1 on DNA lesi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xue, Huijun, Bhardwaj, Amit, Yin, Yandong, Fijen, Carel, Ephstein, Anastasiya, Zhang, Lianglin, Ding, Xia, Pascal, John M., VanArsdale, Todd L., Rothenberg, Eli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451145/ https://www.ncbi.nlm.nih.gov/pubmed/36070389 http://dx.doi.org/10.1126/sciadv.abq0414

Ejemplares similares

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA
por: Langelier, Marie-France, et al.
Publicado: (2023)

PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
por: Đukić, Nina, et al.
Publicado: (2023)

Single-virus tracking reveals variant SARS-CoV-2 spike proteins induce ACE2-independent membrane interactions
por: Christie, Shaun M., et al.
Publicado: (2022)

PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib
por: Ding, Xia, et al.
Publicado: (2022)

Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer
por: Li, Peng, et al.
Publicado: (2023)

RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer
por: Miao, Chenkui, et al.
Publicado: (2022)

Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1
por: Ryan, Kevin, et al.
Publicado: (2021)

Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer
por: Zhang, Xudong, et al.
Publicado: (2023)

Temporal landscape of mitochondrial proteostasis governed by the UPR(mt)
por: Uoselis, Louise, et al.
Publicado: (2023)

Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury
por: Lau, Arthur, et al.
Publicado: (2022)

Vitamin B(6) is governed by the local compartmentalization of metabolic enzymes during growth
por: Franco, Carolina N., et al.
Publicado: (2023)

Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair
por: Liu, Liu, et al.
Publicado: (2022)

The phosphoinositide signature guides the final step of plant cytokinesis
por: Lebecq, Alexis, et al.
Publicado: (2023)

KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation
por: Jiang, Zhen, et al.
Publicado: (2022)

Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer
por: Brown, Meredith S., et al.
Publicado: (2022)

FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer
por: Liu, Yajie, et al.
Publicado: (2023)

V(D)J Recombination: Recent Insights in Formation of the Recombinase Complex and Recruitment of DNA Repair Machinery
por: Christie, Shaun M., et al.
Publicado: (2022)

Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies
por: Yélamos, José, et al.
Publicado: (2020)

PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling
por: van Beek, Lotte, et al.
Publicado: (2021)

Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans
por: Chen, Xu, et al.
Publicado: (2022)

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
por: Langelier, Marie-France, et al.
Publicado: (2014)

A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment
por: Tergemina, Emmanuel, et al.
Publicado: (2022)

Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins
por: Dybkov, Olexandr, et al.
Publicado: (2023)

A fitness trade-off between growth and survival governed by Spo0A-mediated proteome allocation constraints in Bacillus subtilis
por: Zhu, Manlu, et al.
Publicado: (2023)

Lnc956-TRIM28-HSP90B1 complex on replication forks promotes CMG helicase retention to ensure stem cell genomic stability and embryogenesis
por: Zhang, Weidao, et al.
Publicado: (2023)

Genomic deciphering of sex determination and unique immune system of a potential model species rare minnow (Gobiocypris rarus)
por: Hu, Xudong, et al.
Publicado: (2022)

PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites
por: Lin, Xiaohui, et al.
Publicado: (2022)

Metabolic synergy in Camelina reproductive tissues for seed development
por: Koley, Somnath, et al.
Publicado: (2022)

PARP inhibitors
por: Anwar, Maheen, et al.
Publicado: (2015)

Are PARPs promiscuous?
por: Feijs, Karla L.H., et al.
Publicado: (2022)

PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs
por: Wang, Luyao, et al.
Publicado: (2017)

Interactions of PARP1 Inhibitors with PARP1-Nucleosome Complexes
por: Maluchenko, Natalya, et al.
Publicado: (2022)

PARP Inhibitors in the Treatment of Early Breast Cancer: The Step Beyond?
por: Gonçalves, Anthony, et al.
Publicado: (2020)

Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression
por: Liu, Chao, et al.
Publicado: (2023)

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo
por: Shao, Zhengping, et al.
Publicado: (2020)

Mono-ADP-ribosylation by PARP10 and PARP14 in genome stability
por: Dhoonmoon, Ashna, et al.
Publicado: (2023)

HIV-1 Vpr induces ciTRAN to prevent transcriptional repression of the provirus
por: Bhardwaj, Vipin, et al.
Publicado: (2023)

Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells
por: Gil-Kulik, Paulina, et al.
Publicado: (2020)

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition
por: Ogden, Tom E H, et al.
Publicado: (2021)

An orthologous gene coevolution network provides insight into eukaryotic cellular and genomic structure and function
por: Steenwyk, Jacob L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k3dp1d4itvkuof6fq67f31s5nb