Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 –tubulin complex

Kinesin superfamily proteins are microtubule-based molecular motors driven by the energy of ATP hydrolysis. Among them, the kinesin-4 family is a unique motor that inhibits microtubule dynamics. Although mutations of kinesin-4 cause several diseases, its molecular mechanism is unclear because of the...

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Detalles Bibliográficos
Autores principales: Taguchi, Shinya, Nakano, Juri, Imasaki, Tsuyoshi, Kita, Tomoki, Saijo-Hamano, Yumiko, Sakai, Naoki, Shigematsu, Hideki, Okuma, Hiromichi, Shimizu, Takahiro, Nitta, Eriko, Kikkawa, Satoshi, Mizobuchi, Satoshi, Niwa, Shinsuke, Nitta, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451533/
https://www.ncbi.nlm.nih.gov/pubmed/36065637
http://dx.doi.org/10.7554/eLife.77877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451533/
https://www.ncbi.nlm.nih.gov/pubmed/36065637
http://dx.doi.org/10.7554/eLife.77877

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