Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis

Despite multiple possible oncogenic mutations in the proto-oncogene KRAS, unique subsets of these mutations are detected in different cancer types. As KRAS mutations occur early, if not being the initiating event, these mutational biases are ostensibly a product of how normal cells respond to the en...

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Detalles Bibliográficos
Autores principales: Le Roux, Özgün, Pershing, Nicole LK, Kaltenbrun, Erin, Newman, Nicole J, Everitt, Jeffrey I, Baldelli, Elisa, Pierobon, Mariaelena, Petricoin, Emanuel F, Counter, Christopher M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451540/
https://www.ncbi.nlm.nih.gov/pubmed/36069770
http://dx.doi.org/10.7554/eLife.75715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451540/
https://www.ncbi.nlm.nih.gov/pubmed/36069770
http://dx.doi.org/10.7554/eLife.75715

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