Structure of the MRAS–SHOC2–PP1C phosphatase complex

RAS–MAPK signalling is fundamental for cell proliferation and is altered in most human cancers(1–3). However, our mechanistic understanding of how RAS signals through RAF is still incomplete. Although studies revealed snapshots for autoinhibited and active RAF–MEK1–14-3-3 complexes(4), the intermedi...

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Detalles Bibliográficos
Autores principales: Hauseman, Zachary J., Fodor, Michelle, Dhembi, Anxhela, Viscomi, Jessica, Egli, David, Bleu, Melusine, Katz, Stephanie, Park, Eunyoung, Jang, Dong Man, Porter, Kathryn A., Meili, Fabian, Guo, Hongqiu, Kerr, Grainne, Mollé, Sandra, Velez-Vega, Camilo, Beyer, Kim S., Galli, Giorgio G., Maira, Saveur-Michel, Stams, Travis, Clark, Kirk, Eck, Michael J., Tordella, Luca, Thoma, Claudio R., King, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452295/
https://www.ncbi.nlm.nih.gov/pubmed/35830882
http://dx.doi.org/10.1038/s41586-022-05086-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452295/
https://www.ncbi.nlm.nih.gov/pubmed/35830882
http://dx.doi.org/10.1038/s41586-022-05086-1

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